The Protective Effects of Pine Pollen on Alcohol Induced Liver Injury
Paper Title: Research on the Protective Effect of Pine Pollen on Injury Caused by Alcohol (2008, Xie Huiping)
The objective of this experiment was to study the protective effect of Pine Pollen on rat models of liver injury caused by alcohol. Rat models of alcoholic liver were established and each group was fed Pine Pollen at different dosages for 30 days. The contents of malondialdehyde (MDA), triglycerides (TG), and reduced glutathione (GSH) in liver tissue were measured, and the pathological and histological changes in the liver were observed.
Results showed that the MDA and TG content in the liver tissue were markedly lower in the Pine Pollen fed group than in those rats in the model control group. The average values of pathological changes in the rat liver were markedly lower in the Pine Pollen group than in the model control group. This experiment showed that Pine Pollen has a significantly protective effect on liver injuries caused by alcohol.
Because of advancements in standards of living, the scope of disease has changed, with an increase in alcoholic liver disease. Alcohol is broken down in the body by enzymes in liver cells. This process creates a lot of reactive oxygen molecules, also called "free radicals," which damage the liver.
This hurts the structure and function of different organelles and enzymes in liver cells. This stops the biosynthesis of GSH, makes SOD less effective as an antioxidant, and causes lipid peroxidation.
Results from the above experiment show that dose-depended intake of Pine Pollen can reduce the content of MDA and TG in the liver tissue of alcoholic liver injured rats, improves the content of reduced glutathione in liver tissue, and reduces the fatty degeneration level of the liver.
In conclusion, Pine Pollen has markedly protective function on alcoholic liver damage.
Impact of Pine Pollen on Weight, Liver Weight, and Hepatosomatic Ratio (x̄±s) |
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|---|---|---|---|---|---|---|---|
| Group | Dosage (mg/kg*bw) | Number | Original Weight (g) | Medium Term Weight (g) | Final Weight (g) | Liver Weight (g) | Hepatosomatic Ratio (%) |
| Negative Control Group | 0 | N=10 | 205.60 ± 12.15 | 282.00 ± 27.79 | 337.30 ± 19.55 | 10.96 ± 0.99 | 3.25 ± 0.26 |
| Model Control Group | 0 | N=10 | 200.80 ± 14.67 | 272.30 ± 10.33 | 333.90 ± 19.46 | 10.37 ± 0.75 | 3.12 ± 0.28 |
| Low Dosage Group | 250 | N=10 | 201.20 ± 10.80 | 270.30 ± 14.24 | 335.40 ± 20.58 | 10.10 ± 1.06 | 3.01 ± 0.27 |
| Medium Dosage Group | 500 | N=10 | 199.20 ± 13.40 | 268.50 ± 21.67 | 334.20 ± 20.25 | 10.98 ± 1.25 | 3.29 ± 0.36 |
| High Dosage Group | 1500 | N=10 | 201.00 ± 14.72 | 270.60 ± 15.62 | 342.30 ± 15.64 | 10.93 ± 0.74 | 3.19 ± 0.17 |
Impact of Pine Pollen Liver Tissue Content of MDA, GSH, and G (Xts) (x̄±s) |
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|---|---|---|---|---|---|
| Group | Dosage (mg/kg*bw) | Number | Original Weight (g) | Medium Term Weight (g) | Final Weight (g) |
| Negative Control Group | 0 | N=10 | 1.79 ± 0.68 | 30.97 ± 4.16 | 1.37 ± 0.25 |
| Model Control Group | 0 | N=10 | 5.16 ± 1.31 | 25.55 ± 6.69 | 2.76 ± 0.84 |
| Low Dosage Group | 250 | N=10 | 3.85 ± 1.29 | 27.94 ± 5.57 | 2.49 ± 0.98 |
| Medium Dosage Group | 500 | N=10 | 3.75 ± 1.21 | 31.97 ± 3.29 | 1.79 ± 0.73 |
| High Dosage Group | 1500 | N=10 | 3.36 ± 0.71 | 33.85 ± 5.69 | 1.72 ± 0.67 |
Pathological Examination of Liver Tissue (x̄±s) |
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|---|---|---|---|
| Group | Dosage (mg/kg*bw) | Number | Hepatic Fat Droplets Grade |
| Negative Control Group | 0 | N=10 | 0.10 ± 0.32 |
| Model Control Group | 0 | N=10 | 3.30 ± 0.48 |
| Low Dosage Group | 250 | N=10 | 2.30 ± 0.82 |
| Medium Dosage Group | 500 | N=10 | 2.20 ± 1.14 |
| High Dosage Group | 1500 | N=10 | 1.90 ± 0.74 |
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