The Therapeutic Effects of Pine Pollen on Benign Prostatic Hyperplasia
Paper Title: Research on the Therapeutic Effect of Pine Pollen on Prostatic Hypertrophy (BPH) in Rats (2005, Cong Tao)
In studying the therapeutic effect of Pine Pollen on rat benign prostatic hypertrophy (BPH), also known as enlarged prostate, and the mechanism of disease of BPH, twenty four SD rats were divided into three groups. The three groups were fed a normal diet. The diets of the second and third groups were supplemented with three starch tablets (as a placebo) and three pine pollen tablets per day, respectively. Additionally, group two and group three were fed together with group one.
After two weeks of feeding, groups two and three were injected with testosterone propionate (4 mg/kg) mixed with olive oil. At the same time, group one was injected with olive oil (1 mL/kg) alone. Two weeks later, the sample slices of prostate were observed, and the sex hormones, trace elements, zinc, copper, and antioxidant enzymes were taken from the blood serum, prostate, and liver. The results showed that the prostate hyperplasia symptoms of the groups fed Pine Pollenwere significantly better than those of the placebo group. The testosterone level of group three was lower than that of group two and there was no distinct difference from the control group. The estradiol level in the blood serum of rats in group three was the lowest. Therefore, the experiment concludes that consumption of Pine Pollen could improve the symptoms of BPH and that the preventive mechanism can regulate sex hormone balance.
Results from Groups One through Three
At present, the index to measure the degree of benign prostatic hypertrophy (BPH) is via prostate index blood tests and biopsy. The above results show that the prostate weight, prostate index, and prostate cell proliferation of the Pine Pollen group of rats were distinctly lower than the placebo group, clearly showing that Pine Pollen has a preventive and therapeutic effect on BPH (Benign Prostatic Hyperplasia).
It is generally recognized that three biochemical mechanisms trigger BHP: male sex hormones, estrogen hormones, and growth factors. The above experiment results show that the serum testosterone content of BPH rats increases greatly, which is because of the testosterone propionate injection. The testosterone level of the Pine Pollen group of rats is obviously lower than the placebo group of rats, and the serum estrogen level is also lower than the other two groups. These differences show that Pine Pollen not only effectively controls rats' serum testosterone level but can also adjust the serum estrogen level as well. These two effects can assist in reducing the hyperplastic prostate and result in a better treatment effect without side effects. The application of this plant male andro-gamete (Pine Pollen) in the treatment of sex organ diseases conforms with the therapeutic principles of Traditional Chinese Medicine.
Additionally, in vitro proliferation experiments were conducted on different sources of cells with Pine Pollen. The results show that cells from the prostate can be inhibited by Pine Pollen while the non-prostate-source cells were not. This demonstrates that Pine Pollen has a selective inhibitory effect on prostatic cell proliferation, and has a better inhibitory effect on hormone insensitive cells than hormone-dependent cells.
Meanwhile, biochemical analysis showed that levels of blood urea, nitrogen, and blood sugar of prostatic hyperplasia rats were lower in the Pine Pollen group than in the control group, and creatinine levels showed a decreasing trend. This means that the liver function of prostatic hyperplasia rats was affected to a certain degree with liver function decreased. Because the weight, serum cholesterol, and triglyceride levels of the Pine Pollen group of rats had a distinct decrease over the control group, we can conclude that Pine Pollen has a positive clinical meaning for middle-aged men, in addition to the positive effects on BHP.
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