Epitalon for Lengthening Telomeres

Telomeres, Aging, and Epitalon

We have written here a few times about the relationship between telomeres and aging, and how while some see telomeres as the holy grail in the key to extending lifespan and quality of life, others are quick to point out a major flaw in the theory.

As a basic introduction, chromosomes (which contain the DNA in a cell) have padding at their ends, called telomeres. Without overcomplicating things, that padding allows the cell to replicate, but each time the cell replicates, the padding gets a little worn out (the telomere shortens). In time, there is no padding left, and the cell enters a stage of "old age" called senescence, where it no longer replicates and starts excreting toxins.

Each type of cell in the body (called a cell line) can replicate a certain number of times, then it enters the state of senescence, and it becomes "old." This is called the Hayflick limit, which was developed in 1961 by Leonard Hayflick. It is a leading theory on aging.

There is an enzyme that helps repair the telomeres and allows the cell to keep replicating. In animal testing, this seems to work great: vastly extending lifespan and pretty much eliminating any signs of normal aging. The enzyme is called telomerase. Some animals produce telomerase, but the adult human largely does not (except in certain circumstances and for certain cell lines). So, many people think that if we can either introduce telomerase to the body or switch on cells to produce telomerase, human lifespan can be extended, and the body could be made younger (as in the animal models). But others say, "not so fast." The discovery of telomerase led to a Nobel Prize in Medicine being awarded to Elizabeth Blackburn and Carol Greider in 2009.

Cancer cells automatically switch on their ability to produce telomerase. This allows cancer cells to replicate rapidly and widely. Without telomerase, cancer would never get a foothold in the body because the cells would just die of old age. So, some researchers worry that if telomerase were to be increased in the body, it would aggravate or exacerbate cancer—it would encourage it. Cells in the body routinely become abnormal/cancerous, but the immune system quickly gobbles them up and neutralizes them. This is happening all the time in the body. When the immune system fails, cancer can develop. So, might it be harmful to add telomerase to a system that continually has cancerous cells developing?

Some humans have higher levels of telomerase with no cancerous consequences. Meditation has been shown to increase levels of telomerase and childhood trauma and stress have been shown to shorten telomeres. A large cohort study that began in 1958 and was published in 2013 showed a direct relationship between childhood stress and a two-fold increase in cancer rates. While no similar study exists tracking meditation and cancer, research has shown that when meditation is used as an adjunct therapy during and after treatment for cancer, many markers of health and quality of life improve. All this is to say that: 1) the relationship between telomeres, telomerase, and cancer is not thoroughly understood to the point that a conclusive causative relationship can be proven; and 2) telomeres and telomerase can be affected by lifestyle, both positively and negatively.

However, this blog post is not about meditation and cellular health or about stress and cellular health. This blog post is about a novel therapeutic approach to repairing telomeres while also inhibiting certain forms of cancer. Epitalon is a peptide (a protein) which consists of only four nucleotides (Ala-Glu-Asp-Gly) that repairs telomeres and has antioxidant and anticancer properties. In animal models (including mammals), therapy with epitalon has proven to be very promising. However, human research trials are non-existent, and research into this peptide in the West is largely absent.

Synthetically Activating Telomerase

Developed in the USSR in the late 1980s by Professor Vladimir Khavinson. Over 100 research papers have been published investigating epitalon, and it has been shown to have several important therapeutic benefits:

1. Epitalon increases resistance to emotional stress by normalizing prolactin levels;
2. Epitalon is able to correct reproductive impairment in rat models when combined with melatonin;
3. Epitalon contributes to the normalization of the hypothalamus when combined with melatonin;
4. Epitalon is a powerful antioxidant;
5. Epitalon decreases age-related changes in immune and neuroendocrine systems;
6. Epitalon activates telomerase, which repairs/lengthens telomeres.

It is important to note that epitalon both lengthens telomeres by activating telomerase, but it does so without any increased incidence of tumors. Epitalon has also been shown to have anti-cancer properties against several types of common cancer, including mammary cancer and colon cancer. Additionally, as epitalon seems to activate/regulate an aging immune system, it can be extrapolated that the overall incidence of cancer would be improved with epitalon therapy, as decreased immune function and cancer bear a causative relationship, as does stress and cancer.

Human trials on epitalon are greatly lacking, and at the moment, epitalon is not available for purchase for human consumption—it is still a research chemical. It is reported that it has been continuously used since its discovery by some, and the internet is awash with self-reports on its effects, but most of those are driven by the desire to promote and sell a product.

The science is promising on epitalon, and over the next year or so, I am sure that we will see an explosion of informal human trials as the peptide gains popularity within the longevity community and among those who are willing to be human guinea pigs.

As mentioned above, several important steps can be taken to decrease the shortening of telomeres and boost telomerase, all of which do not involve the use of chemicals with little human research behind them or expensive products to buy. Minimizing stress and practicing meditation are available to most. Eliminating light pollution and supplementing with melatonin may help increase pineal gland function, which could have a similar effect as epitalon supplementation. Extracts of astragalus have also been shown to increase telomerase.

For those who want to self-experiment with epitalon, do your research and buy it from a reputable domestic company with a public presence and a longstanding reputation for providing quality peptides and other research chemicals.

Epitalon can be administered orally, nasally, and intramuscularly (through injection). More is needed when taken orally, less is needed intramuscularly, and nasal administration falls somewhere in the lower middle. For most people, nasal administration will be the preferred route, as injections are complicated and taking the peptide orally would quickly become cost-prohibitive. Expect to pay about $200 for a month of treatment with epitalon.